Indentical Twins: Pinpointing Environmental Impact on the Epigenome
1. Often, the physical characteristics of genetically identical twins become increasingly different as they age, even at the molecular level. Explain why this is so. (use the terms "environment" and "epigenome")
For both twins, they are exposed to the same environment early in life, but as they age, the environments begin to differ. For instance, one twin could be a social people-person. The other could become a quiet, shy adult later on and they might not be very successful.
2. Name 3-4 environmental factors that influence the epigenome.
Diet can have an affect, as well as differences in physical activity, exposure to toxins, and stress.
3. What is an imprinted gene?
An imprinted gene is a gene with epigenetic tags left on it after reproduction and during embryo development.
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Your Environment, Your Epigenome
1. Discuss factors in your daily life (ie. diet, exercise, stress, etc.) that could be affecting your epigenome.
Factors in my life that affect my life include diet, for instance. I personally have a healthily diet and I eat my 5 servings of vegetables and fruit every day. This allows me to be healthy, energized, and alert. I haven't been sick with a flu or even a cough for several years, and this is because of my diet. I exercise a good amount each day, which allows me to stay fit. I do receive a large amount of stress over time and this hurts me by adding worries in my life. Also, stress blocks out other thoughts, but I can quickly get over it.
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Lick Your Rats
1. Explain how a high nurturing mother rat shapes her pup's epigenome, and what that pup's response to stress would be.
A high nurturing mother rat would change her pup's epigenome by loosening it and allowing stress to be quickly dismissed. This allows more methyl to be released and sent away from the gene, and the loosened gene also allows GR protein to form in larger amounts, letting the rat pup calm faster.
2. In rats, does licking by the mother activate, or deactivate her pup's GR gene?
Licking activates the GR gene.
3. Explain how cortisol and the GR protein work together in the brain to relax a rat pup. You may draw a diagram.
Cortisol is the calming hormone released in the rats fight or flight response. More GR proteins allow more cortisol to attach, so that the rat can calm down at fast or slow speeds.
4. The rat nurturing example shows us how parental behavior can shape the behavior of their offspring on a biochemical level. Relate this to humans and think about the personal and social implications. Record your thoughts.
If parents nurture their children very well, those children are going to be able to withstand stress and the related subjects much more than children who were say, abused, by their parents. Those abused children would have a large amount of fear in their lives, and they would be anxious. The well nurtured children would probably become social and positive, while the badly nurtured children would end up lonely and worried.
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Nutrition & the Epigenome
1. Explain how the food we eat affects gene expression.
The food we eat affects gene expression by being broken down and combined to form molecules and particles that the body can utilize every day. For instance, some foods are formed into methyl tags, which are important because they silence genes.
2. Can the diets of parents affect their offspring's epigenome?
Yes, the diets of parents can affect their offsprings epigenome, and this is because whatever nutrients the mother recieves during childbirth are passed down to the child. Say, a mother drinks alcohol. Her child would be harmed because the alcohol would affect genes and brain cells.
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EPIGENETICS & THE HUMAN BRAIN
1. How does Dietary methyl influence gene expression ?
Dietary methyl affects gene expression by stably altering gene expression (turning some genes on and others off).
2. Why do Toxins affect gene methylation?
Toxins can not only poison people, but they can also harm unborn babies. Toxins can change gene methylation by reducing or increasing methyl group amounts. Drugs such as cocaine can give long-term gene damage or changes even.